Home >Pharmaceutical > Ethyl 6,8-dichlorooctanoate
- Chemical Name: Ethyl 6,8-dichlorooctanoate
- CAS No.: 1070-64-0
Factory Sells Best Quality Ethyl 6,8-dichlorooctanoate 1070-64-0 with GMP standards
- Molecular Formula: C10H18Cl2O2
- Molecular Weight: 241.158
- Appearance/Colour: Colorless to yellowish transparent liquid
- Vapor Pressure: 0.00233mmHg at 25°C
- Refractive Index: n20/D 1.462(lit.)
- Boiling Point: 288.5 °C at 760 mmHg
- Flash Point: 105.1 °C
- PSA： 26.30000
- Density: 1.094 g/cm3
- LogP: 3.34620
Ethyl 6,8-dichlorooctanoate(Cas 1070-64-0) Usage
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Flammability and Explosibility |
Notclassified |
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Synthesis |
Dichloroethane in the organic solvent, 6-hydroxy -Chloro - octanoic acid ethyl ester with chlorinated reagent solid phosgene inN, N-dimethyl benzyl amine for the acid-binding agentEthyl 6-hydroxy-8-chlorooctanoate,Chlorination reagents,N, N-dimethylbenzylamine molar ratio1: 1.05: 0.12,The organic solvent was reacted with 6-hydroxy-8-The weight ratio of ethyl chlorocaprylate was1: 2.4 at a temperature ofN, N-dimethylbenzylamine was added dropwise at 10℃,Insulation temperature of 75 ,Insulation time 150min,In the reaction solution obtained,Water layer, water and 6 - hydroxy -8-chloro-ethyl octanoate weight ratio of 1:3, the upper organic phase.Vacuum distillation to collect vacuum 5mmHg,A temperature of 172-176℃,Ethyl 6,8-dichlorooctanoate,Product mol yield 95.68%, Purity 96.65%The bottom of the liquid base to adjust the pH value of 11,Layered,The upper layer was dewatered with sodium sulfateN, N-dimethylbenzylamine,The molar yield of the product was 96.69%Purity 99.71%. |
InChI:InChI=1/C10H18Cl2O2/c1-2-14-10(13)6-4-3-5-9(12)7-8-11/h9H,2-8H2,1H3
1070-64-0 Relevant articles
Method for preparing 6,8-dichloroethyl caprylate
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, (2021/03/13)
The invention provides a method for prep...
A method for the preparation of 6, 8 - dichloro octanoic acid ethyl ester (by machine translation)
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Paragraph 0014; 0015; 0016; 0017; 0018; 0019; 0020; 0021, (2017/08/29)
The invention discloses a lipoic acid is...
Preparation method of ethyl 6,8-dichlorocaprylate
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Paragraph 0047; 0048; 0049, (2016/10/17)
The invention relates to a preparation m...
1070-64-0 Process route
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1070-65-1
6-hydroxy-8-chlorooctanoic acid ethyl ester
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1070-64-0
6,8-dichlorooctanoic acid ethyl ester
| Conditions | Yield |
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With
phosgene; N,N'-dimethylbenzylamine;
In
1,2-dichloro-ethane;
at 10 - 75 ℃;
for 2.5h;
Concentration;
Solvent;
Reagent/catalyst;
Temperature;
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96.69%
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With
pyridine; thionyl chloride; benzene;
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|
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With
thionyl chloride;
In
toluene;
at 100 ℃;
for 5h;
Reagent/catalyst;
Solvent;
Cooling with ice;
Large scale;
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480 kg
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C10 H20 O4
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1070-64-0
6,8-dichlorooctanoic acid ethyl ester
| Conditions | Yield |
|---|---|
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With
thionyl chloride;
at 80 ℃;
for 4h;
Reagent/catalyst;
Temperature;
Alkaline conditions;
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87%
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1070-64-0 Upstream products
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1070-65-1
6-hydroxy-8-chlorooctanoic acid ethyl ester
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626-86-8
adipinic acid monoethyl ester
-
22054-13-3
7-hydroxyheptanal
-
6149-48-0
ethyl 7-hydroxyheptanoate
1070-64-0 Downstream products
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41443-60-1
(+)-6,8-dichloro-octanoic acid
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1456816-63-9
N'-(4-chlorobenzylidene)-5-(1,2-diselenolan-3-yl)pentanehydrazide
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1456816-65-1
N'-(2-chlorobenzylidene)-5-(1,2-diselenolan-3-yl)pentanehydrazide
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1456816-66-2
N'-(2-hydroxybenzylidene)-5-(1,2-diselenolan-3-yl)pentanehydrazide