Home >Pharmaceutical > 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
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- Chemical Name: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
- CAS No.: 1016636-76-2
Quality products?make an important contribution to long-term revenue and profitability. Manufacturer supply high quality 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2 with GMP standards
1.What is the 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one ?
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.
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![2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one](/upload/2026/11/ccbc806759da4ff28effacd14ff84467_b12605ed-11a4-4779-ad1a-c56c15b36767.png)
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1013916-37-4
2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one
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![2-chloro-5-methyl-6-bromo-8-cyclopentylpyridine[2,3-d]pyrimidin-8-hydro-7-one](/upload/2026/11/cdbe10a2eff2445794973ae048c4550c_9607f6f6-1355-4175-94fb-586911b297d9.png)
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1016636-76-2
2-chloro-5-methyl-6-bromo-8-cyclopentylpyridine[2,3-d]pyrimidin-8-hydro-7-one
| Conditions | Yield |
|---|---|
|
With
N-Bromosuccinimide; oxalic acid; acetic anhydride;
In
acetonitrile;
at 60 ℃;
for 12h;
|
98.1%
|
|
With
N-Bromosuccinimide; oxalic acid;
In
acetonitrile;
at 55 - 65 ℃;
for 24h;
Reagent/catalyst;
Solvent;
Temperature;
Industrial scale;
|
92%
|
|
With
N-Bromosuccinimide; oxalic acid;
In
acetonitrile;
at 65 ℃;
for 12h;
Large scale;
Green chemistry;
|
92%
|
|
With
bromine; acetic acid; potassium bromide;
at 55 ℃;
for 1h;
Reagent/catalyst;
Temperature;
|
90%
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 15 ℃;
for 7h;
Inert atmosphere;
Heating;
|
88.3%
|
|
With
N-Bromosuccinimide; oxalic acid;
In
acetonitrile;
|
88%
|
|
With
N-Bromosuccinimide; oxalic acid;
In
N,N-dimethyl-formamide;
at 65 ℃;
for 4h;
Concentration;
Temperature;
|
88%
|
|
With
bromine;
In
chloroform;
at 50 ℃;
for 8h;
Reagent/catalyst;
Solvent;
Temperature;
Green chemistry;
|
88%
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 6.5h;
Temperature;
Inert atmosphere;
|
88.3%
|
|
With
N-Bromosuccinimide; oxalic acid;
In
acetonitrile;
at 60 ℃;
|
87%
|
|
With
bromine; sodium acetate;
In
acetic acid;
at 20 - 50 ℃;
for 0.333333h;
|
83.1%
|
|
With
bromine; sodium acetate; acetic acid;
at 20 - 50 ℃;
|
83.1%
|
|
With
bromine; potassium acetate; acetic acid;
at 50 ℃;
for 35h;
|
61%
|
|
With
bromine; sodium acetate; acetic acid;
at 50 ℃;
for 35h;
Inert atmosphere;
|
290 mg
|
|
With
bromine; sodium acetate; acetic acid;
at 50 ℃;
for 72h;
Inert atmosphere;
|
-
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23755-73-9
triethyl bromophosphonoacetate
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1244949-62-9
C11 H14 ClN3 O
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1016636-76-2
2-chloro-5-methyl-6-bromo-8-cyclopentylpyridine[2,3-d]pyrimidin-8-hydro-7-one
| Conditions | Yield |
|---|---|
|
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
80%
|
2.What is the CAS number for 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one ?
The CAS number of 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one is 1016636-76-2.
More information of 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2 are:
|
CAS?Number |
1016636-76-2 |
|
Density |
1.645±0.06 g/cm3(Predicted) |
|
Boiling Point |
468.4±45.0 °C(Predicted) |
|
HS CODE |
2933990090 |
|
PSA |
47.78000 |
|
LogP |
3.63090 |
|
Pka |
-0.61±0.20(Predicted) |
3.What are another words for 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one ?
Synonyms?for?6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2:6-Bromo-2-chloro-8-cyclopentyl-5-methyl-PYRIDO[2,3-D]pyrimidin-7(8H)-one; 6-broMo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one; Palbociclib intermediate; Palbociclib Intermediate-2; 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
4.What is the molecular formula of 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one?
The chemical formula of ?6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one is?C13 H13 BrClN3 O which containing 13 Carbon atoms,13 Hydrogen atoms,1 Bromine atoms,1 Chlorine atoms,3 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight of??6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one?is 342.623.
5.What is 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one (1016636-76-2) used for?
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one is a complex organic compound characterized by its unique molecular structure. It is a derivative of pyrido[2,3-d]pyrimidin-7(8H)-one, featuring a cyclopentyl group at the 8th position, a methyl group at the 5th position, a bromine atom at the 6th position, and a chlorine atom at the 2nd position. 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one holds potential applications in the pharmaceutical industry due to its ability to inhibit specific protein kinases, such as CDK4 and CDK6.
InChI:InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3
Relevant articles related to 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one:
|
Article |
Source |
|
Preparation method of compound containing chlorobromopyrrole pyrimidinone structure |
- Paragraph 0037-0054, (2021/03/11) |
|
Preparation method of CDK4/6 kinase inhibitor SHR6390 |
- Paragraph 0056; 0080-0087, (2021/05/12) |
6.Buy 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one with the best price .
Tianjin Tianhan Chemicals Co.,Ltd is a quality supplier of 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2.